溶(róng)解(jiě)性 易(yì)溶(róng)於(yú)氯仿(fǎng)，溶於(yú)甲醇(chún)，乙醇，微(wēi)溶於水(shuǐ)
存貯條(tiáo)件 儲存溫(wēn)度(dù)2-8℃
描述
別名 (-)-石杉鹼甲(jiǎ);(-)-Selagine
生化機理(lǐ)
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease.
應用 石杉(shān)鹼(jiǎn)甲不僅通過抑製膽鹼酯酶活性(xìng)，還(huán)可以(yǐ)通過(guò)影響自(zì)由基(jī)係統，降低生長(cháng)抑(yì)素(sù)，細胞內[Ca2+]，穀氨酸含(hán)量，提高鈣調(tiáo)蛋白(CaM)和鈣(gài)調(tiáo)蛋白的(dí)信(xìn)使核(hé)糖(táng)核酸(CaM mRNA)表(biǎo)達水平等多(duō)種藥(yào)理(lǐ)機(jī)製，提高認知(zhī)功能和學習記(jì)憶(yì)能(néng)力(lì)。