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相(xiāng)關(guān)產(chǎn)品(pǐn)
中(zhōng)藥標(biāo)準(zhǔn)品
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產品(pǐn)編(biān)號 |
英文名稱 |
CAS號 |
包裝 |
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553-21-9 |
Costundide |
553-21-9 |
可根(gēn)據客(kè)戶要(yào)求(qiú)訂製(zhì) |
英(yīng)文(wén)名(míng)稱(chēng)：Costundide
CAS號：553-21-9
分(fēn)析標(biāo)準品(pǐn),>98%
分子式 C15H20O2 分子量232.32
基(jī)本(běn)信息(xī):
密度(dù)1.03
溶(róng)解(jiě)性 Soluble in ethanol (50 mM), DMSO (47 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).,
存(cún)貯(zhù)條件 儲存(cún)溫(wēn)度-20°C
描(miáo)述(shù)
產品(pǐn)介紹(shào) Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway
別(bié)名(míng) ;(3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one
生化機(jī)理
Description:
IC50 Value: 6.2 - 9.8 g/mL(sarcoma cells viability)[3]
Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.
in vitro: Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. However, costunolide suppressed nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression via inhibition of c-Fos transcriptional activity without affecting RANKL-induced c-Fos expression. The inhibitory effects ofcostunolide were rescued by overexpression of constitutively active (CA)-NFATc1 [1]. Exposure of T24 cells to costunolide was also associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and it
溶(róng)解(jiě)性 Soluble in ethanol (50 mM), DMSO (47 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).,
存(cún)貯(zhù)條件 儲存(cún)溫(wēn)度-20°C
描(miáo)述(shù)
產品(pǐn)介紹(shào) Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway
別(bié)名(míng) ;(3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one
生化機(jī)理
Description:
IC50 Value: 6.2 - 9.8 g/mL(sarcoma cells viability)[3]
Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.
in vitro: Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. However, costunolide suppressed nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression via inhibition of c-Fos transcriptional activity without affecting RANKL-induced c-Fos expression. The inhibitory effects ofcostunolide were rescued by overexpression of constitutively active (CA)-NFATc1 [1]. Exposure of T24 cells to costunolide was also associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and it
- 上一(yī)條(tiáo)：七葉(yè)苷培養基250g
- 下(xià)一(yī)條(tiáo)：(+)-兒(ér)茶素(sù)
