首頁 > 產(chǎn)品中心(xīn) > 科研抗體(tǐ) > 標記一(yī)抗
產品(pǐn)中(zhōng)心
標(biāo)記(jì)一抗
FITC標記(jì)的(dí)β澱粉(fěn)樣前(qián)體蛋白結合蛋白2抗(kàng)體(tǐ)（X11β）
文(wén)字：[大][中(zhōng)][小(xiǎo)]
2017-5-2 瀏覽(lǎn)次數(shù)：1480
英文(wén)名(míng)稱Anti-APBA2/FITC
中(zhōng)文名稱(chēng):FITC標記的β澱粉樣(yàng)前(qián)體(tǐ)蛋白結(jié)合蛋白2抗(kàng)體(tǐ)（X11β）
別 名Adapter protein X11beta; Amyloid beta A4 precursor protein-binding family A member 2; APBA2; APBA2_HUMAN; D15S1518E; HsT16821; LIN 10; Mint 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 beta; X11l.
規格(gé):100ul
說 明(míng) 書100ul
研(yán)究領域細胞生物 神(shén)經(jīng)生物學(xué) Alzheimer's
抗(kàng)體來(lái)源Rabbit
克(kè)隆(lóng)類型Polyclonal
交叉反(fǎn)應(yīng) Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep,
產(chǎn)品應用(yòng)ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)82kDa
性(xìng) 狀Lyophilized or Liquid
濃 度(dù)1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human APBA2 (351-450aa)
亞(yà) 型(xíng)IgG
純(chún)化(huà)方(fāng)法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條(tiáo)件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹background:
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3)
Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Subunit:
Monomer.
Subcellular Location:
Endoplasmic reticulum. Golgi apparatus.Note=Golgi localization is dependent on ligand binding.
Tissue Specificity:
Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.
中(zhōng)文名稱(chēng):FITC標記的β澱粉樣(yàng)前(qián)體(tǐ)蛋白結(jié)合蛋白2抗(kàng)體(tǐ)（X11β）
別 名Adapter protein X11beta; Amyloid beta A4 precursor protein-binding family A member 2; APBA2; APBA2_HUMAN; D15S1518E; HsT16821; LIN 10; Mint 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 beta; X11l.
詳細介(jiè)紹：
規格(gé):100ul
說 明(míng) 書100ul
研(yán)究領域細胞生物 神(shén)經(jīng)生物學(xué) Alzheimer's
抗(kàng)體來(lái)源Rabbit
克(kè)隆(lóng)類型Polyclonal
交叉反(fǎn)應(yīng) Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep,
產(chǎn)品應用(yòng)ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)82kDa
性(xìng) 狀Lyophilized or Liquid
濃 度(dù)1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human APBA2 (351-450aa)
亞(yà) 型(xíng)IgG
純(chún)化(huà)方(fāng)法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條(tiáo)件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關(guān)資料：
產(chǎn)品介紹background:
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3)
Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Subunit:
Monomer.
Subcellular Location:
Endoplasmic reticulum. Golgi apparatus.Note=Golgi localization is dependent on ligand binding.
Tissue Specificity:
Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.
