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FITC標記的磷(lín)酸化芳(fāng)香(xiāng)胺(àn)N-乙(yǐ)酰化轉(zhuǎn)移酶抗(kàng)體(tǐ)
英(yīng)文(wén)名稱(chēng)Anti-phospho-AANAT (Thr29)/FITC
中文(wén)名(míng)稱:FITC標記的(dí)磷(lín)酸化芳香(xiāng)胺N-乙酰化(huà)轉移酶抗體(tǐ)
別(bié) 名(míng)p-AANAT(Thr29); p-AANAT(T29); AANAT(phospho Thr29); p-AANAT(phospho-T29); Serotonin N-acetyltransferase (phospho T29); AANAT (phospho-Thr29); AANAT; Arylalkylamine N acetyltransferase; SNAT_HUMAN; Serotonin N-acetyltransferase; SNAT; Serotonin acetylase; Aralkylamine N-acetyltransferase; AA-NAT.
規格(gé):100ul
說 明 書100ul
產品類(lèi)型磷酸化抗體
研(yán)究(jiū)領域(yù)腫(zhǒng)瘤(liú) 細(xì)胞(bāo)生(shēng)物 免(miǎn)疫(yì)學 神(shén)經(jīng)生物學 信號(hào)轉導(dǎo) 新陳(chén)代謝
抗(kàng)體來源Rabbit
克(kè)隆(lóng)類型Polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Chicken, Dog, Pig,
產(chǎn)品(pǐn)應(yīng)用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原(yuán)KLH conjugated synthesised phosphopeptide derived from human AANAT around the phosphorylation site of Thr29
亞(yà) 型IgG
純化方法(fǎ)affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介(jiè)紹(shào)background:
Arylalkylamine N-acetyltransferase belongs to the superfamily of acetyltransferases. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night. This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle
Function:
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Subunit:
Monomer. Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
Post-translational modifications:
cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
中文(wén)名(míng)稱:FITC標記的(dí)磷(lín)酸化芳香(xiāng)胺N-乙酰化(huà)轉移酶抗體(tǐ)
別(bié) 名(míng)p-AANAT(Thr29); p-AANAT(T29); AANAT(phospho Thr29); p-AANAT(phospho-T29); Serotonin N-acetyltransferase (phospho T29); AANAT (phospho-Thr29); AANAT; Arylalkylamine N acetyltransferase; SNAT_HUMAN; Serotonin N-acetyltransferase; SNAT; Serotonin acetylase; Aralkylamine N-acetyltransferase; AA-NAT.
詳細介紹(shào)：
規格(gé):100ul
說 明 書100ul
產品類(lèi)型磷酸化抗體
研(yán)究(jiū)領域(yù)腫(zhǒng)瘤(liú) 細(xì)胞(bāo)生(shēng)物 免(miǎn)疫(yì)學 神(shén)經(jīng)生物學 信號(hào)轉導(dǎo) 新陳(chén)代謝
抗(kàng)體來源Rabbit
克(kè)隆(lóng)類型Polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Chicken, Dog, Pig,
產(chǎn)品(pǐn)應(yīng)用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原(yuán)KLH conjugated synthesised phosphopeptide derived from human AANAT around the phosphorylation site of Thr29
亞(yà) 型IgG
純化方法(fǎ)affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資料：
產(chǎn)品介(jiè)紹(shào)background:
Arylalkylamine N-acetyltransferase belongs to the superfamily of acetyltransferases. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night. This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle
Function:
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Subunit:
Monomer. Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
Post-translational modifications:
cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
