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英文(wén)名(míng)稱(chēng)Anti-phospho-APE(Ser1417)/FITC
中(zhōng)文名稱(chēng):FITC標(biāo)記(jì)的磷酸(suān)化(huà)肌動(dòng)蛋(dàn)白(bái)結(jié)合蛋白(bái)Girdin抗體
別 名Girdin (phospho S1417); p-APE(Ser1417); Akt phosphorylation enhancer; APE; Coiled coil domain containing protein 88A; G alpha interacting vesicle associated protein; Girders of actin filament; GIV; HkRP1; Hook related protein 1; AKT iphosphorylation enhancer; Akt phosphorylation enhancer; Ccdc88a; GIV; GRDN; GRDN_HUMAN; HkRP1; Hook related protein 1; Hook-related protein 1; KIAA1212.
規格(gé):100ul
說 明 書100ul
產品類型(xíng)磷酸化抗體
研(yán)究領域腫瘤 細胞(bāo)生物(wù) 神(shén)經生(shēng)物學 細胞粘附分(fēn)子(zǐ) 細(xì)胞(bāo)骨架
抗(kàng)體來(lái)源Rabbit
克(kè)隆(lóng)類(lèi)型(xíng)Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse,
產品(pǐn)應(yīng)用(yòng)ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子(zǐ) 量(liáng)206kDa
細胞定(dìng)位(wèi)細胞(bāo)膜
性(xìng) 狀(zhuàng)Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫(yì) 原(yuán)KLH conjugated synthesised phosphopeptide derived from human APE around the phosphorylation site of Ser1417
亞 型(xíng)IgG
純化(huà)方法affinity purified by Protein A
儲(chǔ) 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條(tiáo)件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹background:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome
Function:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Subunit:
Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1. Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [PI(4)P] and weakly with phosphatidylinositol 3-phosphate [PI(3)P]. Interacts with microtubules. Interacts with actin through its C-terminal domain. Interacts with the C-terminus of AKT1/PKB.
Subcellular Location:
Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides.
Tissue Specificity:
Expressed ubiquitously.
Post-translational modifications:
Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.
中(zhōng)文名稱(chēng):FITC標(biāo)記(jì)的磷酸(suān)化(huà)肌動(dòng)蛋(dàn)白(bái)結(jié)合蛋白(bái)Girdin抗體
別 名Girdin (phospho S1417); p-APE(Ser1417); Akt phosphorylation enhancer; APE; Coiled coil domain containing protein 88A; G alpha interacting vesicle associated protein; Girders of actin filament; GIV; HkRP1; Hook related protein 1; AKT iphosphorylation enhancer; Akt phosphorylation enhancer; Ccdc88a; GIV; GRDN; GRDN_HUMAN; HkRP1; Hook related protein 1; Hook-related protein 1; KIAA1212.
詳細介(jiè)紹：
規格(gé):100ul
說 明 書100ul
產品類型(xíng)磷酸化抗體
研(yán)究領域腫瘤 細胞(bāo)生物(wù) 神(shén)經生(shēng)物學 細胞粘附分(fēn)子(zǐ) 細(xì)胞(bāo)骨架
抗(kàng)體來(lái)源Rabbit
克(kè)隆(lóng)類(lèi)型(xíng)Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse,
產品(pǐn)應(yīng)用(yòng)ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子(zǐ) 量(liáng)206kDa
細胞定(dìng)位(wèi)細胞(bāo)膜
性(xìng) 狀(zhuàng)Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫(yì) 原(yuán)KLH conjugated synthesised phosphopeptide derived from human APE around the phosphorylation site of Ser1417
亞 型(xíng)IgG
純化(huà)方法affinity purified by Protein A
儲(chǔ) 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條(tiáo)件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資料：
產品介紹background:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome
Function:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Subunit:
Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1. Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [PI(4)P] and weakly with phosphatidylinositol 3-phosphate [PI(3)P]. Interacts with microtubules. Interacts with actin through its C-terminal domain. Interacts with the C-terminus of AKT1/PKB.
Subcellular Location:
Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides.
Tissue Specificity:
Expressed ubiquitously.
Post-translational modifications:
Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.
- 上(shàng)一條：FITC標(biāo)記的小腦脊髓共濟失調蛋白(bái)3抗(kàng)體
- 下(xià)一(yī)條(tiáo)：FITC標(biāo)記的錨蛋白重復(fù)結(jié)構域(yù)蛋白17抗(kàng)體
