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英(yīng)文(wén)名(míng)稱(chēng)Anti-ANKRD28/FITC
中文名稱:FITC標(biāo)記的錨蛋(dàn)白(bái)重復域(yù)28抗(kàng)體
別 名ANKRD 28; ANKRD-28; Ankyrin repeat domain 28; KIAA0379; Phosphatase interactor targeting K protein; Phosphatase interactor targeting protein hnRNP K; PITK; ANR28_HUMAN.
規格(gé):100ul
說 明 書100ul
研究(jiū)領域細胞生(shēng)物(wù) 信號轉(zhuǎn)導 細(xì)胞(bāo)周(zhōu)期(qī)蛋白 激酶和磷酸酶(méi) 表觀(guān)遺傳(chuán)學
抗體來源Rabbit
克隆類型Polyclonal
交叉(chā)反(fǎn)應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
產品應(yīng)用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量113kDa
性(xìng) 狀Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫(yì) 原KLH conjugated synthetic peptide derived from human ANKRD28
亞 型IgG
純(chún)化(huà)方法affinity purified by Protein A
儲 存 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存(cún)條(tiáo)件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品(pǐn)介紹(shào)background:
ANKRD28 selectively inhibits the phosphatase activity of PPP1C and targets PPP1C to modulate HNRPK phosphorylation. It contains twenty seven ANK repeats. There are two named isoforms
Function:
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.
Subunit:
Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3.
Subcellular Location:
Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli.
Similarity:
Contains 27 ANK repeats.
Database links:
UniProtKB/Swiss-Prot: O15084.5
中文名稱:FITC標(biāo)記的錨蛋(dàn)白(bái)重復域(yù)28抗(kàng)體
別 名ANKRD 28; ANKRD-28; Ankyrin repeat domain 28; KIAA0379; Phosphatase interactor targeting K protein; Phosphatase interactor targeting protein hnRNP K; PITK; ANR28_HUMAN.
詳細(xì)介(jiè)紹：
規格(gé):100ul
說 明 書100ul
研究(jiū)領域細胞生(shēng)物(wù) 信號轉(zhuǎn)導 細(xì)胞(bāo)周(zhōu)期(qī)蛋白 激酶和磷酸酶(méi) 表觀(guān)遺傳(chuán)學
抗體來源Rabbit
克隆類型Polyclonal
交叉(chā)反(fǎn)應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
產品應(yīng)用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量113kDa
性(xìng) 狀Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫(yì) 原KLH conjugated synthetic peptide derived from human ANKRD28
亞 型IgG
純(chún)化(huà)方法affinity purified by Protein A
儲 存 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存(cún)條(tiáo)件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相(xiāng)關(guān)資料：
產品(pǐn)介紹(shào)background:
ANKRD28 selectively inhibits the phosphatase activity of PPP1C and targets PPP1C to modulate HNRPK phosphorylation. It contains twenty seven ANK repeats. There are two named isoforms
Function:
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.
Subunit:
Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3.
Subcellular Location:
Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli.
Similarity:
Contains 27 ANK repeats.
Database links:
UniProtKB/Swiss-Prot: O15084.5
- 上一條(tiáo)：FITC標(biāo)記的α蛋白激酶3抗(kàng)體(tǐ)
- 下(xià)一條(tiáo)：FITC標(biāo)記(jì)的(dí)細胞(bāo)分裂(liè)周期(qī)蛋(dàn)白16抗體(tǐ)
