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標(biāo)記一抗(kàng)
英文名(míng)稱Anti-AMSH/FITC
中文名稱:FITC標(biāo)記的信號轉(zhuǎn)導(dǎo)銜接(jiē)結(jié)合(hé)蛋(dàn)白(bái)抗體
別 名(míng)Associated molecule with the SH3 domain of STAM; Endosome associated ubiquitin isopeptidase; Endosome-associated ubiquitin isopeptidase; STABP_HUMAN; STAM binding protein; STAM-binding protein; STAMBP.
規格(gé):100ul
說(shuō) 明 書(shū)100ul
研(yán)究(jiū)領(lǐng)域細胞生(shēng)物 細(xì)胞(bāo)周(zhōu)期蛋白(bái) 結(jié)合(hé)蛋(dàn)白(bái) 表觀遺(yí)傳學
抗(kàng)體(tǐ)來源Rabbit
克隆類(lèi)型Polyclonal
交叉(chā)反應(yīng) Human, Mouse, Rat, Dog, Horse, Rabbit,
產(chǎn)品應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子(zǐ) 量47kDa
細胞定(dìng)位(wèi)細胞膜
性(xìng) 狀Lyophilized or Liquid
濃 度(dù)1mg/ml
免(miǎn) 疫 原(yuán)KLH conjugated synthetic peptide derived from human AMSH
亞 型IgG
純(chún)化方法(fǎ)affinity purified by Protein A
儲 存(cún) 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存(cún)條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介(jiè)紹(shào)background:
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7
Function:
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
Subcellular Location:
Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
Tissue Specificity:
Ubiquitously expressed.
Post-translational modifications:
Phosphorylated after BMP type I receptor activation.
Ubiquitinated by SMURF2 in the presence of RNF11.
Similarity:
Belongs to the peptidase M67C family.
Contains 1 MPN (JAB/Mov34) domain.
中文名稱:FITC標(biāo)記的信號轉(zhuǎn)導(dǎo)銜接(jiē)結(jié)合(hé)蛋(dàn)白(bái)抗體
別 名(míng)Associated molecule with the SH3 domain of STAM; Endosome associated ubiquitin isopeptidase; Endosome-associated ubiquitin isopeptidase; STABP_HUMAN; STAM binding protein; STAM-binding protein; STAMBP.
詳細介(jiè)紹：
規格(gé):100ul
說(shuō) 明 書(shū)100ul
研(yán)究(jiū)領(lǐng)域細胞生(shēng)物 細(xì)胞(bāo)周(zhōu)期蛋白(bái) 結(jié)合(hé)蛋(dàn)白(bái) 表觀遺(yí)傳學
抗(kàng)體(tǐ)來源Rabbit
克隆類(lèi)型Polyclonal
交叉(chā)反應(yīng) Human, Mouse, Rat, Dog, Horse, Rabbit,
產(chǎn)品應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子(zǐ) 量47kDa
細胞定(dìng)位(wèi)細胞膜
性(xìng) 狀Lyophilized or Liquid
濃 度(dù)1mg/ml
免(miǎn) 疫 原(yuán)KLH conjugated synthetic peptide derived from human AMSH
亞 型IgG
純(chún)化方法(fǎ)affinity purified by Protein A
儲 存(cún) 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存(cún)條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資料：
產品介(jiè)紹(shào)background:
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7
Function:
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
Subcellular Location:
Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
Tissue Specificity:
Ubiquitously expressed.
Post-translational modifications:
Phosphorylated after BMP type I receptor activation.
Ubiquitinated by SMURF2 in the presence of RNF11.
Similarity:
Belongs to the peptidase M67C family.
Contains 1 MPN (JAB/Mov34) domain.
