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英(yīng)文名稱Anti-ACVR1B/FITC
中文(wén)名稱(chēng):FITC標記的激活素(sù)A受(shòu)體(tǐ)1B抗體
別 名Activin A receptor type 1B; Activin A receptor type II like kinase 4; Activin A type 1B receptor; Activin A type IB receptor; Activin receptor like kinase 4; Activin receptor type 1B; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR IB; ACTR-IB; ACTRIB; ACV1B_HUMAN; ACVR 1B; ACVR1B; ACVRLK 4; ACVRLK4; ALK 4; ALK-4; ALK4; Serine(threonine) protein kinase receptor R2; Serine/threonine-protein kinase receptor R2; SKR 2; SKR2.
規(guī)格(gé):100ul
說(shuō) 明(míng) 書100ul
研究領(lǐng)域(yù)細(xì)胞生(shēng)物 免疫學 信號轉導 幹(gān)細胞(bāo) 激(jī)酶(méi)和磷酸(suān)酶 結(jié)合蛋白(bái)
抗體來(lái)源Rabbit
克(kè)隆類型Polyclonal
交叉反(fǎn)應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
產品應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)55kDa
細(xì)胞(bāo)定(dìng)位細胞(bāo)膜(mó)
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human ACVR1B
亞 型IgG
純化(huà)方(fāng)法affinity purified by Protein A
儲 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹(shào)background:
[FUNCTION]Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
中文(wén)名稱(chēng):FITC標記的激活素(sù)A受(shòu)體(tǐ)1B抗體
別 名Activin A receptor type 1B; Activin A receptor type II like kinase 4; Activin A type 1B receptor; Activin A type IB receptor; Activin receptor like kinase 4; Activin receptor type 1B; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR IB; ACTR-IB; ACTRIB; ACV1B_HUMAN; ACVR 1B; ACVR1B; ACVRLK 4; ACVRLK4; ALK 4; ALK-4; ALK4; Serine(threonine) protein kinase receptor R2; Serine/threonine-protein kinase receptor R2; SKR 2; SKR2.
詳細介(jiè)紹(shào)：
規(guī)格(gé):100ul
說(shuō) 明(míng) 書100ul
研究領(lǐng)域(yù)細(xì)胞生(shēng)物 免疫學 信號轉導 幹(gān)細胞(bāo) 激(jī)酶(méi)和磷酸(suān)酶 結(jié)合蛋白(bái)
抗體來(lái)源Rabbit
克(kè)隆類型Polyclonal
交叉反(fǎn)應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
產品應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)55kDa
細(xì)胞(bāo)定(dìng)位細胞(bāo)膜(mó)
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human ACVR1B
亞 型IgG
純化(huà)方(fāng)法affinity purified by Protein A
儲 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相(xiāng)關資(zī)料(liào)：
產品介紹(shào)background:
[FUNCTION]Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
- 上一條(tiáo)：FITC標記(jì)的酰基(jī)輔(fǔ)酶(méi)A結合結構域蛋白6抗體(tǐ)
- 下(xià)一條(tiáo)：FITC標(biāo)記(jì)的氨(ān)基(jī)酰化酶(méi)1抗體
