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英文名稱(chēng)Anti-AF 4/FITC
中文(wén)名稱:FITC標(biāo)記的(dí)原癌基(jī)因(yīn)AF4蛋白抗體(tǐ)
別(bié) 名(míng)AF 4; AF 4 protein; AF-4 protein; AF4/FMR2 family member 1; AFF 1; AFF1; AFF1_HUMAN; ALL1 fused gene from chromosome 4; ALL1-fused gene from chromosome 4 protein; FEL; MLLT2; MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2; Protein AF-4; Protein FEL; Proto-oncogene AF4; AF4; PBM1. .
規格(gé):100ul
說 明 書100ul
研(yán)究(jiū)領域腫瘤 細胞生物(wù) 免疫(yì)學(xué) 染色質和核(hé)信號 信(xìn)號轉(zhuǎn)導(dǎo)
抗(kàng)體(tǐ)來源Rabbit
克隆(lóng)類型(xíng)Polyclonal
交叉反應 Human, Mouse, Rat, Rabbit,
產(chǎn)品(pǐn)應(yīng)用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量133kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human AF 4 protein
亞(yà) 型IgG
純化方(fāng)法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存(cún)條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹background:
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.
中文(wén)名稱:FITC標(biāo)記的(dí)原癌基(jī)因(yīn)AF4蛋白抗體(tǐ)
別(bié) 名(míng)AF 4; AF 4 protein; AF-4 protein; AF4/FMR2 family member 1; AFF 1; AFF1; AFF1_HUMAN; ALL1 fused gene from chromosome 4; ALL1-fused gene from chromosome 4 protein; FEL; MLLT2; MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2; Protein AF-4; Protein FEL; Proto-oncogene AF4; AF4; PBM1. .
詳(xiáng)細介紹：
規格(gé):100ul
說 明 書100ul
研(yán)究(jiū)領域腫瘤 細胞生物(wù) 免疫(yì)學(xué) 染色質和核(hé)信號 信(xìn)號轉(zhuǎn)導(dǎo)
抗(kàng)體(tǐ)來源Rabbit
克隆(lóng)類型(xíng)Polyclonal
交叉反應 Human, Mouse, Rat, Rabbit,
產(chǎn)品(pǐn)應(yīng)用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量133kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human AF 4 protein
亞(yà) 型IgG
純化方(fāng)法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存(cún)條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資料：
產品介紹background:
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.
