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英文名稱 Anti-ABLIM3
中(zhōng)文名稱 肌(jī)動蛋白結(jié)合(hé)蛋白LIM蛋(dàn)白3抗(kàng)體
別 名 abLIM-3; Ablim3; ABLM3_HUMAN; Actin binding LIM protein 3; Actin binding LIM protein family member 3; Actin-binding LIM protein 3; Actin-binding LIM protein family member 3; HMFN1661; KIAA0843.
濃(nóng) 度(dù) 1mg/1ml
規 格 0.2ml/200μg
抗體來源(yuán) Rabbit
克(kè)隆(lóng)類型(xíng) polyclonal
交叉(chā)反(fǎn)應 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
產品類(lèi)型(xíng) 一抗
研究領(lǐng)域 細胞生物 信號轉導 結合蛋(dàn)白 細胞(bāo)骨架(jià)
蛋白(bái)分子量 predicted molecular weight: 79kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human ABLIM3
亞 型(xíng) IgG
純化(huà)方(fāng)法(fǎ) affinity purified by Protein A
儲 存(cún) 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品(pǐn)應用(yòng) WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟(là)切片需做(zuò)抗(kàng)原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription.
Function : May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
Subunit : Directly interacts with F-actin and ABRA.
Subcellular Location : Cytoplasm.
Tissue Specificity : Expressed predominantly in heart and brain.
Similarity : Contains 1 HP (headpiece) domain.
Contains 4 LIM zinc-binding domains.
Database links : UniProtKB/Swiss-Prot: O94929.3
中(zhōng)文名稱 肌(jī)動蛋白結(jié)合(hé)蛋白LIM蛋(dàn)白3抗(kàng)體
別 名 abLIM-3; Ablim3; ABLM3_HUMAN; Actin binding LIM protein 3; Actin binding LIM protein family member 3; Actin-binding LIM protein 3; Actin-binding LIM protein family member 3; HMFN1661; KIAA0843.
詳細介紹(shào)：
濃(nóng) 度(dù) 1mg/1ml
規 格 0.2ml/200μg
抗體來源(yuán) Rabbit
克(kè)隆(lóng)類型(xíng) polyclonal
交叉(chā)反(fǎn)應 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
產品類(lèi)型(xíng) 一抗
研究領(lǐng)域 細胞生物 信號轉導 結合蛋(dàn)白 細胞(bāo)骨架(jià)
蛋白(bái)分子量 predicted molecular weight: 79kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human ABLIM3
亞 型(xíng) IgG
純化(huà)方(fāng)法(fǎ) affinity purified by Protein A
儲 存(cún) 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品(pǐn)應用(yòng) WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟(là)切片需做(zuò)抗(kàng)原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相(xiāng)關資料：
產品介紹 The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription.
Function : May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
Subunit : Directly interacts with F-actin and ABRA.
Subcellular Location : Cytoplasm.
Tissue Specificity : Expressed predominantly in heart and brain.
Similarity : Contains 1 HP (headpiece) domain.
Contains 4 LIM zinc-binding domains.
Database links : UniProtKB/Swiss-Prot: O94929.3
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