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英文(wén)名稱 Anti-ATP6V0D2/V-ATPase D2
中(zhōng)文名(míng)稱(chēng) ATP6V0D2蛋白抗(kàng)體
別(bié) 名(míng) ATP6D2; ATPase H+ transporting lysosomal 38kDa V0 subunit D; ATPase H+ transporting lysosomal 38kDa V0 subunit D isoform 2; ATPase H+ transporting lysosomal 38kDa V0 subunit D2; FLJ38708; V ATPase subunit d 2; Vacuolar ATP synthase subunit d 2; Vacuolar proton pump subunit d 2; VMA 6; VMA6; VA0D2_HUMAN.
濃 度 1mg/1ml
規 格(gé) 0.2ml/200μg
抗體來(lái)源(yuán) Rabbit
克隆類(lèi)型(xíng) polyclonal
交(jiāo)叉(chā)反(fǎn)應 Human, Mouse, Rat, Dog, Pig, Sheep
產品類型(xíng) 一抗
研(yán)究領域(yù) 腫(zhǒng)瘤 細胞(bāo)生物(wù) 信號轉導(dǎo) 新陳代謝(xiè)
蛋白(bái)分子量(liáng) predicted molecular weight: 40kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫(yì) 原 KLH conjugated synthetic peptide derived from human ATP6V0D2/V-ATPase D2
亞(yà) 型 IgG
純化方(fāng)法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品(pǐn)應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟切片需做抗(kàng)原(yuán)修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. V-ATPase D2 is a 350 amino acid protein that is expressed in kidney, lung and osteoclast. V-ATPase D2 has been implicated as a regulator of urine acidification, osteoclast fusion and bone formation. Furthermore, V-ATPase D2 has been identified as a dendritic cell marker.
Function : Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).
Subunit : V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Subcellular Location : Apical plasma membrane.
Tissue Specificity : Kidney, osteoclast and lung.
Similarity : Belongs to the V-ATPase V0D/AC39 subunit family.
Database links : UniProtKB/Swiss-Prot: Q8N8Y2.1
中(zhōng)文名(míng)稱(chēng) ATP6V0D2蛋白抗(kàng)體
別(bié) 名(míng) ATP6D2; ATPase H+ transporting lysosomal 38kDa V0 subunit D; ATPase H+ transporting lysosomal 38kDa V0 subunit D isoform 2; ATPase H+ transporting lysosomal 38kDa V0 subunit D2; FLJ38708; V ATPase subunit d 2; Vacuolar ATP synthase subunit d 2; Vacuolar proton pump subunit d 2; VMA 6; VMA6; VA0D2_HUMAN.
詳細(xì)介紹：
濃 度 1mg/1ml
規 格(gé) 0.2ml/200μg
抗體來(lái)源(yuán) Rabbit
克隆類(lèi)型(xíng) polyclonal
交(jiāo)叉(chā)反(fǎn)應 Human, Mouse, Rat, Dog, Pig, Sheep
產品類型(xíng) 一抗
研(yán)究領域(yù) 腫(zhǒng)瘤 細胞(bāo)生物(wù) 信號轉導(dǎo) 新陳代謝(xiè)
蛋白(bái)分子量(liáng) predicted molecular weight: 40kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫(yì) 原 KLH conjugated synthetic peptide derived from human ATP6V0D2/V-ATPase D2
亞(yà) 型 IgG
純化方(fāng)法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品(pǐn)應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟切片需做抗(kàng)原(yuán)修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關資料(liào)：
產(chǎn)品介紹 Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. V-ATPase D2 is a 350 amino acid protein that is expressed in kidney, lung and osteoclast. V-ATPase D2 has been implicated as a regulator of urine acidification, osteoclast fusion and bone formation. Furthermore, V-ATPase D2 has been identified as a dendritic cell marker.
Function : Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).
Subunit : V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Subcellular Location : Apical plasma membrane.
Tissue Specificity : Kidney, osteoclast and lung.
Similarity : Belongs to the V-ATPase V0D/AC39 subunit family.
Database links : UniProtKB/Swiss-Prot: Q8N8Y2.1
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