產(chǎn)品(pǐn)中心
一(yī)抗(kàng)
英(yīng)文名(míng)稱 Anti-Attractin
中文名稱 Attractin蛋白(bái)抗體(tǐ)
別 名 ATRN; ATRN_HUMAN; attractin 2; Attractin; attractin-2; DPPT L; DPPT-L; KIAA0548; Mahogany homolog; mahogany protein; MGCA.
濃 度(dù) 1mg/1ml
規 格 0.2ml/200μg
抗(kàng)體來源(yuán) Rabbit
克(kè)隆類(lèi)型 polyclonal
交叉反(fǎn)應 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep
產品類型 一(yī)抗(kàng)
研(yán)究(jiū)領(lǐng)域 腫瘤(liú) 細胞生物(wù) 神(shén)經生(shēng)物(wù)學 細胞粘附(fù)分子 t-淋巴細(xì)胞(bāo)
蛋白分(fēn)子(zǐ)量 predicted molecular weight: 150kDa
性 狀 Lyophilized or Liquid
免 疫(yì) 原 KLH conjugated synthetic peptide derived from human Attractin
亞(yà) 型(xíng) IgG
純(chún)化方法 affinity purified by Protein A
儲(chǔ) 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品(pǐn)應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟(là)切(qiē)片(piàn)需(xū)做抗原(yuán)修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介(jiè)紹 Mahogany (MG), originally identified as a protein involved in pigmentation, acts in conjunction with melanocortin receptors to suppress diet-induced obesity. Mahogany contains a single transmembrane domain, and it is expressed in a broad range of tissues, including the hypothalamus and pigment cells. Mutations within the mahogany gene were shown to rescue agouti-lethal-yellow mutant mice from obesity. The extracellular domain of mouse mahogany is the ortholog of the human protein attractin. Attractin (also designated DPPT-L) is a human serum glycoprotein and is a member of the CUB family of cell adhesion and guidance proteins. Attractin is expressed on activated T cells and is released from the cells 48 to 72 hours after activation.
Function : Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system.
Subunit : Monomer and homotrimer.
Subcellular Location : Secreted and Cell membrane.
Tissue Specificity : Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.
Post-translational modifications : Heavily glycosylated.
Similarity : Contains 1 C-type lectin domain.
Contains 1 CUB domain.
Contains 1 EGF-like domain.
Contains 6 Kelch repeats.
Contains 2 laminin EGF-like domains.
Contains 4 PSI domains.
Database links : UniProtKB/Swiss-Prot: O75882.2
attractin在(zài)黑色素(sù)沉(chén)著，調(tiáo)節運動(dòng)行(háng)為和基礎(chǔ)代謝(xiè)，中(zhōng)樞神(shén)經的(dí)形成及(jí)功(gōng)能，協(xié)調T細胞與(yǔ)巨噬細(xì)胞之(zhī)間的反(fǎn)應(yīng)等(děng)方(fāng)麵(miàn)都發(fā)揮著作(zuò)用。
中文名稱 Attractin蛋白(bái)抗體(tǐ)
別 名 ATRN; ATRN_HUMAN; attractin 2; Attractin; attractin-2; DPPT L; DPPT-L; KIAA0548; Mahogany homolog; mahogany protein; MGCA.
詳(xiáng)細介(jiè)紹：
濃 度(dù) 1mg/1ml
規 格 0.2ml/200μg
抗(kàng)體來源(yuán) Rabbit
克(kè)隆類(lèi)型 polyclonal
交叉反(fǎn)應 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep
產品類型 一(yī)抗(kàng)
研(yán)究(jiū)領(lǐng)域 腫瘤(liú) 細胞生物(wù) 神(shén)經生(shēng)物(wù)學 細胞粘附(fù)分子 t-淋巴細(xì)胞(bāo)
蛋白分(fēn)子(zǐ)量 predicted molecular weight: 150kDa
性 狀 Lyophilized or Liquid
免 疫(yì) 原 KLH conjugated synthetic peptide derived from human Attractin
亞(yà) 型(xíng) IgG
純(chún)化方法 affinity purified by Protein A
儲(chǔ) 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品(pǐn)應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟(là)切(qiē)片(piàn)需(xū)做抗原(yuán)修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關資(zī)料：
產(chǎn)品介(jiè)紹 Mahogany (MG), originally identified as a protein involved in pigmentation, acts in conjunction with melanocortin receptors to suppress diet-induced obesity. Mahogany contains a single transmembrane domain, and it is expressed in a broad range of tissues, including the hypothalamus and pigment cells. Mutations within the mahogany gene were shown to rescue agouti-lethal-yellow mutant mice from obesity. The extracellular domain of mouse mahogany is the ortholog of the human protein attractin. Attractin (also designated DPPT-L) is a human serum glycoprotein and is a member of the CUB family of cell adhesion and guidance proteins. Attractin is expressed on activated T cells and is released from the cells 48 to 72 hours after activation.
Function : Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system.
Subunit : Monomer and homotrimer.
Subcellular Location : Secreted and Cell membrane.
Tissue Specificity : Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.
Post-translational modifications : Heavily glycosylated.
Similarity : Contains 1 C-type lectin domain.
Contains 1 CUB domain.
Contains 1 EGF-like domain.
Contains 6 Kelch repeats.
Contains 2 laminin EGF-like domains.
Contains 4 PSI domains.
Database links : UniProtKB/Swiss-Prot: O75882.2
attractin在(zài)黑色素(sù)沉(chén)著，調(tiáo)節運動(dòng)行(háng)為和基礎(chǔ)代謝(xiè)，中(zhōng)樞神(shén)經的(dí)形成及(jí)功(gōng)能，協(xié)調T細胞與(yǔ)巨噬細(xì)胞之(zhī)間的反(fǎn)應(yīng)等(děng)方(fāng)麵(miàn)都發(fā)揮著作(zuò)用。
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