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英文(wén)名稱(chēng) Anti-BORA
中文名(míng)稱： 調節(jié)中心(xīn)體(tǐ)分離(lí)早期(qī)相關(guān)激(jī)酶BORA抗體
別 名 Aurora borealis; bora; BORA_HUMAN; C13orf34; Chromosome 13 open reading frame 34; FLJ22624; HsBora; Protein aurora borealis; RP11-342J4.2.
濃(nóng) 度 1mg/1ml
規(guī) 格 0.1ml/200μg
抗體來源 Rabbit
克隆(lóng)類(lèi)型 polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep
產品類(lèi)型(xíng) 一(yī)抗
研(yán)究領域 細(xì)胞(bāo)生物 信(xìn)號(hào)轉(zhuǎn)導(dǎo) 激(jī)酶(méi)和磷酸(suān)酶(méi) 細胞分化(huà)
蛋(dàn)白(bái)分(fēn)子(zǐ)量 predicted molecular weight: 61kDa
性(xìng) 狀 Lyophilized or Liquid
免(miǎn) 疫 原 KLH conjugated synthetic peptide derived from human BORA
亞(yà) 型 IgG
純化(huà)方(fāng)法 affinity purified by Protein A
儲 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品(pǐn)應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟(là)切(qiē)片需(xū)做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹(shào) Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.
Function : Required for the activation of Aurora-A (AURKA/STK6) at the onset of mitosis.
Subunit : Interacts with AURKA.
Post-translational modifications : Phosphorylated by AURKA/STK6.
Similarity : Belongs to the BORA family.
Database links : UniProtKB/Swiss-Prot: Q6PGQ7.2
中文名(míng)稱： 調節(jié)中心(xīn)體(tǐ)分離(lí)早期(qī)相關(guān)激(jī)酶BORA抗體
別 名 Aurora borealis; bora; BORA_HUMAN; C13orf34; Chromosome 13 open reading frame 34; FLJ22624; HsBora; Protein aurora borealis; RP11-342J4.2.
詳細(xì)介紹：
濃(nóng) 度 1mg/1ml
規(guī) 格 0.1ml/200μg
抗體來源 Rabbit
克隆(lóng)類(lèi)型 polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep
產品類(lèi)型(xíng) 一(yī)抗
研(yán)究領域 細(xì)胞(bāo)生物 信(xìn)號(hào)轉(zhuǎn)導(dǎo) 激(jī)酶(méi)和磷酸(suān)酶(méi) 細胞分化(huà)
蛋(dàn)白(bái)分(fēn)子(zǐ)量 predicted molecular weight: 61kDa
性(xìng) 狀 Lyophilized or Liquid
免(miǎn) 疫 原 KLH conjugated synthetic peptide derived from human BORA
亞(yà) 型 IgG
純化(huà)方(fāng)法 affinity purified by Protein A
儲 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品(pǐn)應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟(là)切(qiē)片需(xū)做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相(xiāng)關(guān)資料(liào)：
產(chǎn)品介紹(shào) Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.
Function : Required for the activation of Aurora-A (AURKA/STK6) at the onset of mitosis.
Subunit : Interacts with AURKA.
Post-translational modifications : Phosphorylated by AURKA/STK6.
Similarity : Belongs to the BORA family.
Database links : UniProtKB/Swiss-Prot: Q6PGQ7.2
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