產(chǎn)品(pǐn)中心
一(yī)抗(kàng)
英文名稱 Anti-CEA/CD66e/CEACAM5(C-terminus)
中(zhōng)文(wén)名稱 癌(ái)胚(pēi)抗(kàng)原抗體（C端）
別 名(míng) Carcino Embryonic Antigen CEA; CEACAM 5; CEACAM-5; Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5; CD66e; CD66e antigen; CEA; CEACAM5; DKFZp781M2392; Meconium antigen 100.
詳細介(jiè)紹(shào)：
濃(nóng) 度(dù) 1mg/1ml
規(guī) 格 0.1ml/100μg 0.2ml/200μg
抗體(tǐ)來(lái)源 Rabbit
克(kè)隆(lóng)類(lèi)型(xíng) polyclonal
交(jiāo)叉(chā)反應(yīng) Human
產品類(lèi)型 一抗(kàng)
研(yán)究(jiū)領(lǐng)域(yù) 腫瘤(liú) 免(miǎn)疫學(xué) 幹細(xì)胞 細胞(bāo)類型標誌(zhì)物(wù) 腫(zhǒng)瘤細胞(bāo)生物標(biāo)誌物(wù)
蛋白(bái)分子(zǐ)量(liáng) predicted molecular weight: 150-200kDa
性(xìng) 狀 Lyophilized or Liquid
免 疫(yì) 原(yuán) KLH conjugated synthetic peptide derived from human CEA/CD66e/CEACAM5(C-terminus)
亞 型 IgG
純化方(fāng)法(fǎ) affinity purified by Protein A
儲 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟切(qiē)片(piàn)需(xū)做抗(kàng)原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保(bǎo)存(cún)條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
相關(guān)資(zī)料：
產品(pǐn)介(jiè)紹(shào) CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Function : Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.
Subunit : Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchor
Tissue Specificity : Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Similarity : Belongs to the immunoglobulin superfamily. CEA family.
CEA是一(yī)種(zhǒng)胚(pēi)胎性抗(kàng)原，主要存在於(yú)胎(tāi)兒(ér)消化道(dào)上(shàng)皮組織，胰腺和肝(gān)癌中(zhōng)。CEA廣泛存在各種(zhǒng)上皮(pí)性(xìng)腫(zhǒng)瘤，尤其(qí)是(shì)胃腸(cháng)道(dào)惡(è)性腫瘤，CEA分布陽性類型(xíng)與(yǔ)腫(zhǒng)瘤(liú)的(dí)惡(è)性度(dù)有關。CEA與EMA一(yī)樣可(kě)作(zuò)為(wéi)上(shàng)皮性(xìng)惡性腫瘤的重要(yào)標記(jì)。
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