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英(yīng)文名(míng)稱 Anti-CYP51A1
中文(wén)名稱 羊(yáng)毛(máo)甾(zāi)醇(chún)14α-去甲(jiǎ)基化(huà)酶蛋(dàn)白抗體
別 名(míng) Lanosterol 14-alpha demethylase; LDM; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase; CP51A_HUMAN.
詳(xiáng)細介(jiè)紹：
濃 度 1mg/1ml
規(guī) 格(gé) 0.2ml /200μg
抗體來源 Rabbit
克(kè)隆類型(xíng) polyclonal
交叉(chā)反(fǎn)應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Sheep
產(chǎn)品(pǐn)類型 一(yī)抗(kàng)
研究(jiū)領域 細胞生物 免疫學
蛋(dàn)白分(fēn)子量 predicted molecular weight: 57kDa
性 狀 Lyophilized or Liquid
免 疫(yì) 原 KLH conjugated synthetic peptide derived from human CYP51A1
亞 型(xíng) IgG
純化(huà)方(fāng)法 affinity purified by Protein A
儲 存(cún) 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應用(yòng) WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切(qiē)片(piàn)需(xū)做抗(kàng)原修(xiū)復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相(xiāng)關資(zī)料：
產(chǎn)品介紹 CYP51A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.
Function : Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Subcellular Location : Endoplasmic reticulum membrane (Potential). Microsome membrane (Potential).
Tissue Specificity : Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung.
Similarity : Belongs to the cytochrome P450 family.
Database links : UniProtKB/Swiss-Prot: Q16850.3
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