產品中(zhōng)心
一抗(kàng)
英(yīng)文名(míng)稱(chēng) Anti-CYP51A1
中文名(míng)稱(chēng) 羊毛(máo)甾醇(chún)14α-去(qù)甲基化酶蛋白抗體(tǐ)
別 名 Lanosterol 14-alpha demethylase; LDM; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase; CP51A_HUMAN.
詳細介(jiè)紹：
濃 度 1mg/1ml
規(guī) 格 0.2ml /200μg
抗體(tǐ)來(lái)源 Rabbit
克隆類(lèi)型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Sheep
產品類型(xíng) 一抗
研(yán)究(jiū)領域 細胞(bāo)生(shēng)物 免(miǎn)疫學
蛋白分(fēn)子量(liáng) predicted molecular weight: 57kDa
性(xìng) 狀(zhuàng) Lyophilized or Liquid
免(miǎn) 疫(yì) 原 KLH conjugated synthetic peptide derived from human CYP51A1
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存(cún) 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品(pǐn)應用(yòng) WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切(qiē)片(piàn)需做抗原(yuán)修(xiū)復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關資料：
產(chǎn)品介紹(shào) CYP51A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.
Function : Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Subcellular Location : Endoplasmic reticulum membrane (Potential). Microsome membrane (Potential).
Tissue Specificity : Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung.
Similarity : Belongs to the cytochrome P450 family.
Database links : UniProtKB/Swiss-Prot: Q16850.3
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