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一抗
英(yīng)文名稱(chēng) Anti-CDC5L
中文名稱(chēng) 細胞分(fēn)裂(liè)周期(qī)蛋白(bái)5樣(yàng)蛋白(bái)抗(kàng)體
別(bié) 名 CDC5; CDC5 cell division cycle 5-like (S. pombe); Cdc5 related protein; CDC5-LIKE; CDC5-like protein; Cdc5-like protein; CEF1; Cell division cycle 5 S. pombe homolog of; Cell division cycle 5-like protein; dJ319D22.1; KIAA0432; PCDC5RP; Pombe Cdc5 related protein; Pombe cdc5-related protein; CDC5L_HUMAN.
詳(xiáng)細介紹：
濃 度 1mg/1ml
規(guī) 格 0.1ml/100μg 0.2ml/200μg
抗(kàng)體來源 Rabbit
克(kè)隆類型(xíng) polyclonal
交(jiāo)叉反(fǎn)應 Human, Mouse
產(chǎn)品類型 一抗(kàng)
研(yán)究領域 細胞生(shēng)物(wù) 免(miǎn)疫學(xué) 染色質和(hé)核(hé)信號(hào) 表觀遺(yí)傳學(xué)
蛋(dàn)白(bái)分(fēn)子(zǐ)量 predicted molecular weight: 92kDa
性(xìng) 狀(zhuàng) Lyophilized or Liquid
免 疫 原(yuán) KLH conjugated synthetic peptide derived from human CDC5L
亞 型 IgG
純化(huà)方(fāng)法 affinity purified by Protein A
儲(chǔ) 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品(pǐn)應用(yòng) WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟(là)切(qiē)片(piàn)需(xū)做抗原(yuán)修(xiū)復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關資料(liào)：
產品介紹 CDC5L is a this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.
Function : DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
Subunit : Homodimer. Interacts with DAPK3 (By similarity). Binds DNA. Binds to adeno-pre-mRNA in an ATP-stimulated manner. Belongs to the spliceosome complex. Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its C-terminus) directly in the complex with PRPF19 and BCAS2. Interacts (via its C-terminus) directly with PRGL1 (via its WD40 repeat domain); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts with CTNNBL1.
Subcellular Location : Nucleus. Nucleus speckle. Cytoplasm. Note=May shuttle between cytoplasm and nucleus.
Tissue Specificity : Ubiquitously expressed in both fetal and adult tissues.
Post-translational modifications : Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.
DISEASE : Note=A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.
Similarity : Belongs to the CEF1 family.
Contains 2 HTH myb-type DNA-binding domains.
Database links : UniProtKB/Swiss-Prot: Q99459.2
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