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中(zhōng)藥(yào)標準品
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產(chǎn)品編(biān)號(hào) |
英文(wén)名稱 |
CAS號(hào) |
包(bāo)裝 |
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Y3713 |
(S)-(+)-Camptothecin |
7689-03-4 |
可(kě)根據客戶要求訂製(zhì) |
產(chǎn)品編(biān)號(hào)：Y3713
英文(wén)名稱：(S)-(+)-Camptothecin
CAS號(hào)：7689-03-4分析標(biāo)準品(pǐn),≥98%
分子式(shì) C20H16N2O4 分(fēn)子量348.35
基本信息:
密(mì)度(dù) 1.51
熔點 259-263°C
存(cún)貯(zhù)條件(jiàn) 貯存溫度2-8℃
描(miáo)述
產(chǎn)品介(jiè)紹 微溶於(yú)乙醇(chún)，氯(lǜ)仿，難(nán)溶於水。與酸(suān)不(bù)能生(shēng)成穩定的(dí)鹽(yán)，與(yǔ)氫(qīng)氧化鈉溶(róng)液加(jiā)熱反應(yīng)可(kě)生成鈉鹽(yán)而溶於(yú)水。鈉(nà)鹽水溶(róng)液黃色(sè)澄明(míng)具藍(lán)色熒(yíng)光
別名 喜(xǐ)樹(shù)鹼(jiǎn) ;4-乙基-4-羥基(jī)-1H-吡喃[3'，4'：6，7]氮(dàn)茚[1，2]喹啉(lán)-3，14(4H，12H)-二酮(tóng);4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
生化機(jī)理
Camptothecin (CPT), a cytotoxic quinoline alkaloid, is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. It has recently been undergoing phase I clinical trials. In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks with excitation wavelengths lambdaex of 215, 255 and 365 nm, separately. Camptothecin shows high activity against various tumor cells.
應用 不可(kě)逆轉地的結合到(dào)DNA拓撲異(yì)構(gòu)酶I復合物(wù)上，影(yǐng)響細胞周(zhōu)期(qī)進程(chéng)
熔點 259-263°C
存(cún)貯(zhù)條件(jiàn) 貯存溫度2-8℃
描(miáo)述
產(chǎn)品介(jiè)紹 微溶於(yú)乙醇(chún)，氯(lǜ)仿，難(nán)溶於水。與酸(suān)不(bù)能生(shēng)成穩定的(dí)鹽(yán)，與(yǔ)氫(qīng)氧化鈉溶(róng)液加(jiā)熱反應(yīng)可(kě)生成鈉鹽(yán)而溶於(yú)水。鈉(nà)鹽水溶(róng)液黃色(sè)澄明(míng)具藍(lán)色熒(yíng)光
別名 喜(xǐ)樹(shù)鹼(jiǎn) ;4-乙基-4-羥基(jī)-1H-吡喃[3'，4'：6，7]氮(dàn)茚[1，2]喹啉(lán)-3，14(4H，12H)-二酮(tóng);4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
生化機(jī)理
Camptothecin (CPT), a cytotoxic quinoline alkaloid, is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. It has recently been undergoing phase I clinical trials. In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks with excitation wavelengths lambdaex of 215, 255 and 365 nm, separately. Camptothecin shows high activity against various tumor cells.
應用 不可(kě)逆轉地的結合到(dào)DNA拓撲異(yì)構(gòu)酶I復合物(wù)上，影(yǐng)響細胞周(zhōu)期(qī)進程(chéng)
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