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英(yīng)文名稱 Anti-Phospho-BAP1(Ser592)
中文名(míng)稱： 磷酸(suān)化(huà)乳腺癌易感(gǎn)基(jī)因(yīn)1抗體(人(rén))
別 名 BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; RNF53 ,Breast cancer susceptbility gene.
濃(nóng) 度 1mg/1ml
規(guī) 格(gé) 0.1ml/100μg
抗(kàng)體(tǐ)來源(yuán) Rabbit
克隆類型(xíng) polyclonal
交叉(chā)反(fǎn)應 Human, Rat, Dog, Rabbit
產品類(lèi)型 一(yī)抗(kàng) 磷酸(suān)化抗(kàng)體
研究領(lǐng)域 腫瘤 免疫(yì)學(xué) 信(xìn)號(hào)轉導 轉錄調節因子 激酶和(hé)磷酸(suān)酶
蛋(dàn)白(bái)分(fēn)子量(liáng) predicted molecular weight: 81kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫 原(yuán) KLH conjugated Synthesised phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592
亞(yà) 型 IgG
純化(huà)方(fāng)法(fǎ) affinity purified by Protein A
儲 存(cún) 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切片(piàn)需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹(shào) This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Subunit : Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1.
Subcellular Location : Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin.
Tissue Specificity : Highly expressed in testis, placenta and ovary. Expressed in breast.
Similarity : Belongs to the peptidase C12 family. BAP1 subfamily.
BRCA1基因(yīn)是(shì)最(zuì)早被發(fā)現的乳(rǔ)腺(xiàn)癌(ái)易(yì)感(gǎn)基(jī)因其(qí)突(tū)變(biàn)和(hé)家族(zú)性乳腺癌，卵(luǎn)巢(cháo)癌的發(fā)病(bìng)有(yǒu)關(guān)。
中文名(míng)稱： 磷酸(suān)化(huà)乳腺癌易感(gǎn)基(jī)因(yīn)1抗體(人(rén))
別 名 BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; RNF53 ,Breast cancer susceptbility gene.
詳(xiáng)細介紹：
濃(nóng) 度 1mg/1ml
規(guī) 格(gé) 0.1ml/100μg
抗(kàng)體(tǐ)來源(yuán) Rabbit
克隆類型(xíng) polyclonal
交叉(chā)反(fǎn)應 Human, Rat, Dog, Rabbit
產品類(lèi)型 一(yī)抗(kàng) 磷酸(suān)化抗(kàng)體
研究領(lǐng)域 腫瘤 免疫(yì)學(xué) 信(xìn)號(hào)轉導 轉錄調節因子 激酶和(hé)磷酸(suān)酶
蛋(dàn)白(bái)分(fēn)子量(liáng) predicted molecular weight: 81kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫 原(yuán) KLH conjugated Synthesised phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592
亞(yà) 型 IgG
純化(huà)方(fāng)法(fǎ) affinity purified by Protein A
儲 存(cún) 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切片(piàn)需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關(guān)資料：
產品介紹(shào) This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Subunit : Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1.
Subcellular Location : Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin.
Tissue Specificity : Highly expressed in testis, placenta and ovary. Expressed in breast.
Similarity : Belongs to the peptidase C12 family. BAP1 subfamily.
BRCA1基因(yīn)是(shì)最(zuì)早被發(fā)現的乳(rǔ)腺(xiàn)癌(ái)易(yì)感(gǎn)基(jī)因其(qí)突(tū)變(biàn)和(hé)家族(zú)性乳腺癌，卵(luǎn)巢(cháo)癌的發(fā)病(bìng)有(yǒu)關(guān)。
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