產品中(zhōng)心
一抗
英(yīng)文名稱 Anti-BPI
中文名稱： 殺菌(jūn)/通透(tòu)性增強蛋(dàn)白抗(kàng)體
別 名(míng) Bactericidal permeability-increasing protein; bactericidal/permeability-increasing protein; BPI; CAP 57; BPI_HUMAN.
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗(kàng)體來源 Rabbit
克隆類型(xíng) polyclonal
交叉反應 Human
產品類(lèi)型 一(yī)抗
研(yán)究領域(yù) 細胞生物 免(miǎn)疫學 細(xì)胞凋亡(wáng) 細菌及病毒 t-淋巴(bā)細胞
蛋(dàn)白(bái)分(fēn)子(zǐ)量 predicted molecular weight: 50kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human BPI
亞 型(xíng) IgG
純化方(fāng)法 affinity purified by Protein A
儲 存(cún) 液(yè) 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切(qiē)片需做抗(kàng)原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條(tiáo)件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品(pǐn)介(jiè)紹(shào) The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.
Function : The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Subunit : Monomer. Homodimer; disulfide-linked.
Subcellular Location : Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Tissue Specificity : Restricted to cells of the myeloid series.
Similarity : Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
殺菌(jūn)／通透(tòu)性增(zēng)加蛋(dàn)白(Bactericidal／permeability-increasing protein，BPI)是(shì)哺(bǔ)乳動物(wù)中(zhōng)性粒細胞(bāo)中(zhōng)存(cún)在(zài)的(dí)一種(zhǒng)鹼(jiǎn)性蛋白，BPI能與(yǔ)革蘭(lán)氏陰性菌脂(zhī)多(duō)糖(táng)結合(hé)，增加外膜(mó)對抗菌藥(yào)物的(dí)通(tōng)透(tòu)性，具有(yǒu)中(zhōng)和內毒素和(hé)殺(shā)滅(miè)細菌(jūn)的生物學作用(yòng)，在(zài)革蘭(lán)氏陰(yīn)性(xìng)菌感染的治療(liáo)方麵有(yǒu)良(liáng)好(hǎo)的發(fā)展前(qián)景。
中文名稱： 殺菌(jūn)/通透(tòu)性增強蛋(dàn)白抗(kàng)體
別 名(míng) Bactericidal permeability-increasing protein; bactericidal/permeability-increasing protein; BPI; CAP 57; BPI_HUMAN.
詳(xiáng)細介(jiè)紹：
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗(kàng)體來源 Rabbit
克隆類型(xíng) polyclonal
交叉反應 Human
產品類(lèi)型 一(yī)抗
研(yán)究領域(yù) 細胞生物 免(miǎn)疫學 細(xì)胞凋亡(wáng) 細菌及病毒 t-淋巴(bā)細胞
蛋(dàn)白(bái)分(fēn)子(zǐ)量 predicted molecular weight: 50kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human BPI
亞 型(xíng) IgG
純化方(fāng)法 affinity purified by Protein A
儲 存(cún) 液(yè) 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切(qiē)片需做抗(kàng)原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條(tiáo)件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關資料(liào)：
產品(pǐn)介(jiè)紹(shào) The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.
Function : The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Subunit : Monomer. Homodimer; disulfide-linked.
Subcellular Location : Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Tissue Specificity : Restricted to cells of the myeloid series.
Similarity : Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
殺菌(jūn)／通透(tòu)性增(zēng)加蛋(dàn)白(Bactericidal／permeability-increasing protein，BPI)是(shì)哺(bǔ)乳動物(wù)中(zhōng)性粒細胞(bāo)中(zhōng)存(cún)在(zài)的(dí)一種(zhǒng)鹼(jiǎn)性蛋白，BPI能與(yǔ)革蘭(lán)氏陰性菌脂(zhī)多(duō)糖(táng)結合(hé)，增加外膜(mó)對抗菌藥(yào)物的(dí)通(tōng)透(tòu)性，具有(yǒu)中(zhōng)和內毒素和(hé)殺(shā)滅(miè)細菌(jūn)的生物學作用(yòng)，在(zài)革蘭(lán)氏陰(yīn)性(xìng)菌感染的治療(liáo)方麵有(yǒu)良(liáng)好(hǎo)的發(fā)展前(qián)景。
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