首頁(yè) > 產品(pǐn)中心 > 科(kē)研抗體(tǐ) > 一抗
產(chǎn)品中心(xīn)
一抗(kàng)
英文(wén)名稱 Anti-Bcl-6/5
中(zhōng)文(wén)名稱(chēng)： 原癌基因Bcl-6抗(kàng)體
別 名 B-cell lymphoma 6 protein isoform 1; zinc finger transcription factor BCL6S; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; Bcl 6； protein LAZ-3; B-cell lymphoma 5 protein; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; zinc finger protein 51; cys-his2 zinc finger transcription factor; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51; BCL6_HUMAN.
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗體來源(yuán) Rabbit
克(kè)隆(lóng)類型 polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit
產品類(lèi)型 一(yī)抗
研究領域 腫(zhǒng)瘤(liú) 免疫(yì)學(xué) 信(xìn)號轉(zhuǎn)導 細(xì)胞(bāo)凋亡 轉錄(lù)調(tiáo)節(jié)因子
蛋白(bái)分(fēn)子(zǐ)量 predicted molecular weight: 78kDa
性 狀 Lyophilized or Liquid
免(miǎn) 疫 原(yuán) KLH conjugated synthetic peptide derived from human Bcl-6
亞(yà) 型 IgG
純化方(fāng)法(fǎ) affinity purified by Protein A
儲 存(cún) 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟(là)切(qiē)片需做抗(kàng)原(yuán)修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保(bǎo)存(cún)條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品(pǐn)介紹(shào) The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq].
Function : Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
Subunit : Homodimer. Interacts (via BTB domain) with BCOR; the interaction is direct. Interacts (via BTB domain) with NCOR2; the interaction is direct. Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.
Subcellular Location : Nucleus (By similarity).
Tissue Specificity : Expressed in germinal center T and B-cells and in primary immature dendritic cells.
Post-translational modifications : Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
Polyubiquitinated. Polyubiquitination leads to degradation by the proteasome.
DISEASE : Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.
Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
Similarity : Contains 1 BTB (POZ) domain.
Contains 6 C2H2-type zinc fingers.
Database links : UniProtKB/Swiss-Prot: P41182.1
中(zhōng)文(wén)名稱(chēng)： 原癌基因Bcl-6抗(kàng)體
別 名 B-cell lymphoma 6 protein isoform 1; zinc finger transcription factor BCL6S; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; Bcl 6； protein LAZ-3; B-cell lymphoma 5 protein; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; zinc finger protein 51; cys-his2 zinc finger transcription factor; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51; BCL6_HUMAN.
詳細(xì)介紹：
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗體來源(yuán) Rabbit
克(kè)隆(lóng)類型 polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit
產品類(lèi)型 一(yī)抗
研究領域 腫(zhǒng)瘤(liú) 免疫(yì)學(xué) 信(xìn)號轉(zhuǎn)導 細(xì)胞(bāo)凋亡 轉錄(lù)調(tiáo)節(jié)因子
蛋白(bái)分(fēn)子(zǐ)量 predicted molecular weight: 78kDa
性 狀 Lyophilized or Liquid
免(miǎn) 疫 原(yuán) KLH conjugated synthetic peptide derived from human Bcl-6
亞(yà) 型 IgG
純化方(fāng)法(fǎ) affinity purified by Protein A
儲 存(cún) 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟(là)切(qiē)片需做抗(kàng)原(yuán)修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保(bǎo)存(cún)條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關資(zī)料(liào)：
產(chǎn)品(pǐn)介紹(shào) The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq].
Function : Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
Subunit : Homodimer. Interacts (via BTB domain) with BCOR; the interaction is direct. Interacts (via BTB domain) with NCOR2; the interaction is direct. Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.
Subcellular Location : Nucleus (By similarity).
Tissue Specificity : Expressed in germinal center T and B-cells and in primary immature dendritic cells.
Post-translational modifications : Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
Polyubiquitinated. Polyubiquitination leads to degradation by the proteasome.
DISEASE : Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.
Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
Similarity : Contains 1 BTB (POZ) domain.
Contains 6 C2H2-type zinc fingers.
Database links : UniProtKB/Swiss-Prot: P41182.1
- 上一條：磷酸化Bcl-10抗體
- 下一條：Bcl-10抗(kàng)體
