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一(yī)抗
英(yīng)文(wén)名稱 Anti-C7
中文名稱(chēng) 補體C7抗體
別 名 C7; CO7_HUMAN; complement component 7; Complement component C7.
詳(xiáng)細介紹：
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗體來(lái)源(yuán) Rabbit
克隆類型 polyclonal
交叉反應 Human, Mouse, Rat, Pig, Cow, Sheep
產(chǎn)品類型(xíng) 一抗
研(yán)究(jiū)領域(yù) 細(xì)胞生物(wù) 免疫(yì)學
蛋白分(fēn)子(zǐ)量 predicted molecular weight: 91kDa
性(xìng) 狀(zhuàng) Lyophilized or Liquid
免(miǎn) 疫 原(yuán) KLH conjugated synthetic peptide derived from human C7
亞(yà) 型(xíng) IgG
純(chún)化(huà)方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟(là)切(qiē)片(piàn)需做(zuò)抗(kàng)原修(xiū)復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條(tiáo)件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相(xiāng)關資(zī)料(liào)：
產品介(jiè)紹
Function : Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
Subunit : Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes. MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
Subcellular Location : Secreted.
Post-translational modifications : C7 has 28 disulfide bridges.
O- and C-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
DISEASE : Defects in C7 are a cause of complement component 7 deficiency (C7D) [MIM:610102]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Similarity : Belongs to the complement C6/C7/C8/C9 family.
Contains 1 EGF-like domain.
Contains 1 LDL-receptor class A domain.
Contains 1 MACPF domain.
Contains 2 Sushi (CCP/SCR) domains.
Contains 2 TSP type-1 domains.
Database links : UniProtKB/Swiss-Prot: P10643.2
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